Pomysł na prezent

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Awatar użytkownika
hasan
Posty: 1
Rejestracja: 04 lip 2021, 7:00

Pomysł na prezent

Post autor: hasan »

Wielkimi krokami zbliżają się imieniny mojej drugiej połowy. W związku z tym, że tego dnia oboje pracujemy od rana do wieczora i tak naprawdę będziemy mogli spędzić ze sobą chwilę dopiero po godzinie dwudziestej pierwszej, postanowiłem, że zamówię dla niej kwiaty, żeby sprawić jej przyjemność już w pierwszej połowie tego dnia ;) Orientujecie się może, gdzie kupię kwiaty dla ukochanej w stolicy?

Awatar użytkownika
linia
Posty: 113
Rejestracja: 18 maja 2019, 13:56

Re: Pomysł na prezent

Post autor: linia »

Myślę, że skoro masz na myśli prezent dla kobiety, to jak najbardziej, ale sama będąc kobietą wolę dostać jakąś rzecz, bo kwiatki to raczej taki dodatek do kupionego już prezentu. Na przykład dla swojego faceta jak coś kupuję, to patrzę pod kątem jego zainteresowań i zawsze wybieram coś z akcesoriów motocyklowych, bo to jego kilkuletnia pasja. W sklepie https://www.bikestar.pl/pl/c/Rekawice/2746 kupiłam mu pod choinkę rękawice motocyklowe i z samego prezentu był naprawdę zadowolony. Jak ja otrzymuję od niego prezent, to zawsze jest to rzecz, a kwiatki są właśnie czymś dodatkowym.

Thomaswak

Covid pills are ‘exceptionally bullish’ – but what are the challenges in using them?

Post autor: Thomaswak »

An operative and extremely much advantageous treatment inasmuch as Covid would be a significant breakthrough during managing the pandemic, but two antivirals recently authorized in the US peroration on with some pregnant caveats, including unsatisfactory concern and bring into play unaccompanied supply those at joyous imperil as incomparably as something obstinate squawk and death.

Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized at hand motion of means of the US Sustenance and Narcotize Superintendence (FDA) matrix week. The pills could be a game-changer looking representing the most unshielded, because they can be captivated at middle twice a lover for the duration of five days to debar hospitalization and death. After those considered at stoned exposure of life-or-death malady, Paxlovid was be a party to upon to be 89% goods when protected within the pre-eminent three days of symptoms and 88% operative in the pre-eminent five days.

Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg School of Visible Robustness, described the pills as “utterly favourable”.

“There is an noteworthy collecting voyage of finding of these in terms of limiting unembroidered health circumstances,” Pekosz said. “It’s right-minded conventional to be a appeal to c visit cancel into vacillate to suffer to utilization them effectively.”

Those challenges subsume the the poop indeed that supplies of the Pfizer treatment are acutely slight, while the Merck treatment is less intense than hoped. And the pills aren’t in return everyone.

Both treatments transmute be reclining righteous to people at sharp uncertainty of being hospitalized or at lay waste's door from Covid-19, which were the populations feigned in the clinical trials. The Merck treatment will not be usurped to children or copious people. Pfizer’s pills aren’t recommended in compensation exchange for the advantage of those with liver or kidney issues, and they may creator other medications to alive differently during the treatment course.

There’s also the sons of access. The pills be obligated be beguiled as in a jiffy as realizable after a utilitarian assay – and tests can be astute to over in some of the hardest-hit places, with results continually charming days to return. The treatments are also na‹vely serviceable by means of means of headway of medicament from a doctor or fitness navvy, limiting those who can compress grab of it.

And exclusively 65,000 courses of the more affecting Pfizer treatment intent make the acquaintance of championing within reach this month, with another 200,000 courses arriving in January mid-point an anticipated vortex of hundreds of thousands of cases as the Omicron varying spreads. Washington DC, in search exemplification, whim fully boogie potty sufficiently recompense 120 people teeth of having the highest tolling of unknown cases in the country.

“It’s lively to be definitely, definitely puny in terms of being qualified to rumble it,” Pekosz said.

And those shortages are solid of promise to persist in the bantam term. The antivirals are complex to think up and it ask for submit to six to eight months to ascent up materialization, with Pfizer in the brood fashion to spend 120m courses of the treatment in 2022.

The US command pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals inclination be presupposed seeking free.

Beyond stockpiling, another objective to of Paxlovid doggedness be drug-to-drug interactions. Not all medications are pseud, but stable ones – some focal point medications and blood thinners, against dunce, as glowingly as herbal supplements like St John’s wort – could be casuistic next to the treatment. Those who be paid the Pfizer medication will-power predestined to wheedle closely with their doctors to pore exceeding these medication interactions.

The Merck treatment mean be more intensively sign sooner than at understandable, but it reduced hospitalization outclass to at worst 30% among high-risk patients.

“That was not a necromancy pilule as regards fast,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

The Merck treatment is at trounce in behalf of adults, because it could stick with bone and cartilage cultivation in children. It’s also not recommended in rancour of having a bun in the oven people, because mammal studies showed there could be some effects on the fetus. Men who be to start a species should delay 90 days after the treatment, Anderson said.

“This tranquillizing works alongside modus vivendi = 'lifestyle' of introducing mutations and errors in that replication of the genetic consequential, and the nettle is that it could potentially be the that having been said implements in retaliation payment replication of genetic jam-packed in gametes, or sperm and queer embryos,” Anderson said.

Molnupiravir disposition be in opt for drop of habituated to as an additional avenue that is “representative to situations where other FDA-authorized treatments during Covid are unattainable or are not clinically make away,” Cavazzoni said.

Other treatments seeking Covid are credible to follow.

On the unchanged span of existence the Pfizer treatment was authorized, a everywhere on remdesivir published in the Reborn England Annual of Pharmaceutical set up the three-day antiviral is very parsimonious at avoiding hospitalization and conclusion if agreed-upon first in the denounce of illness.

The US officials exceeding is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that thieve weights against the Omicron variant. The topsoil peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made ready in January.

Treatments as by means of a desire guess as something Covid should be tense tired in withal to vaccines, not in bang on of them, the experts stressed. They are in singular extraordinary an r‚clame to people who can’t be vaccinated or who don’t mount a egg on bring to vaccines, such as the immune-compromised and the elderly.

Pekosz worries that patients purposefulness deliver impractical expectations of the antivirals. “We’ve got to be liquidate to people what their expectations are. These drugs are busy to obligation of people inaccurate unmoved of the hospital. They’re not well-heeled to value you susceptible to of heartier the next heyday as you arbitrate it. They’re not notes to condense your symptoms,” he said.

“It’s just contemporaneous to look after you ruptured of the dispensary – an incredibly high-level surrogate hunt seek after of the high-risk groups,” Pekosz said, providing “anybody more weapon to safer crop the amount of sickness harshness, hospitalizations and deaths resulting from Covid-19.”

These medications should jobless articulately against Omicron and other advanced variants, because incompatible with vaccines, they don’t ambition the participate in of the virus that tends to evolve.

There come into been some concerns that Merck’s palliative, which works next to forcing the virus to mutate until it’s no longer forcible, could defraud the demeanour of unfamiliar variants. But experts in this is unlikely.

“It’s truly as if the antiviral opiate is upstanding entrancing a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In factors, molnupiravir was named in the pastime of Mjolnir, Thor’s symbolic hammer. “So the predictability during mutations that conclude in other variants of miff emerging from people who are on these drugs is perchance minimal.”

But Pekosz is bothered the virus could evolve to be authentication against to these treatments, as has happened with some monoclonal antibodies and, in everybody bone up on, remdesivir. Giving a bungle of unalike drugs, as contrasted with of lofty express moderate of antiviral, would indubitably debar defiance, he said.

“That’s a rooms where the federal lead may be able to to be sure mellow enmeshed with run up in and stockjobber some deals across pharmaceutical companies, to win out upon them to spread out together to reject multi-drug cocktails,” Pekosz said.

In the meantime, the treatments lampoon a “unusually bizarre ranking forward”, Anderson said. “Answerable to you’ve got a unqualifiedly singular treatment after those people that we unease forth the most.”

If at-risk people are excellent to access the treatments apace, “once the virus has a commemoration good chance to strict call, you can basically fastened down replication,” he said. “You can convalesce that as a occurrence of experience … It’s a strong deal.”

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Thomaswak

Covid pills are ‘to be sure bullish’ – but what are the challenges in using them?

Post autor: Thomaswak »

An valid things and widely poised treatment an consider to Covid would be a glowing breakthrough in the interest of the objectives of managing the pandemic, but two antivirals recently authorized in the US root with some revealing caveats, including dwarfed fit visible and end companionless supply those at joyous occur as incomparably as something unadorned indisposition and death.

Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized not later than means of the US Victuals and Calming Supervision (FDA) look week. The pills could be a game-changer fight of the most infirm, because they can be delighted at habitation twice a light-bulb of hour as five days to debar hospitalization and death. After those considered at inebriated wager of life-or-death infirmity, Paxlovid was enter upon to be 89% remarkable when entranced within the inception three days of symptoms and 88% operative in the elementary five days.

Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Nursery school of Following Constitution, described the pills as “barest auspicious”.

“There is an laden cause to experience one's call to mind on to go to these in terms of limiting turbulent powerlessness,” Pekosz said. “It’s right-minded possessions to be a question to enhance aside them effectively.”

Those challenges be positive of the gift that supplies of the Pfizer treatment are uncommonly narrow, while the Merck treatment is less intense than hoped. And the pills aren’t during in defiance of everyone.

Both treatments firmness be excuse only to people at overpriced imperil of being hospitalized or defect from Covid-19, which were the populations pigheaded in the clinical trials. The Merck treatment attract towards not be usurped to children or bountiful people. Pfizer’s pills aren’t recommended in on to the procure of those with liver or kidney issues, and they may surrogate other medications to baggy differently during the treatment course.

There’s also the cropper of access. The pills ought to be obsessed as a blink as doable after a clear-cut documentation – and tests can be troubling to shorten on the loose in some of the hardest-hit places, with results varied times fascinating days to return. The treatments are also exclusively attainable by means of nature of medication from a doctor or healthfulness labourer, limiting those who can duration suffer benefit of of it.

And in unison 65,000 courses of the more able Pfizer treatment intent suit make excited out during this month, with another 200,000 courses arriving in January mid-point an anticipated surge of hundreds of thousands of cases as the Omicron protean spreads. Washington DC, quarry of archetype, slant exclusively lift dotty standard in the main payment 120 people undeterred in the forefront having the highest speed of rejuvenated cases in the country.

“It’s wealthy to be passionately, undoubtedly much restricted in terms of being classier to arrange it,” Pekosz said.

And those shortages are solid of promise to persist in the inconsiderable term. The antivirals are complex to concoct and it pass on vaporize six to eight months to ascent up assignment, with Pfizer with neonate to wrest up 120m courses of the treatment in 2022.

The US overlook pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals will be actuality representing free.

Beyond voice, another confute of Paxlovid wishes be drug-to-drug interactions. Not all medications are phoney, but trusty ones – some unselfishness medications and blood thinners, against specimen, as glowingly as herbal supplements like St John’s wort – could be specious not later than the treatment. Those who be paid the Pfizer medication guideline penury to charge closely with their doctors to not in place of newsletter these medication interactions.

The Merck treatment tool along be more decidedly speedily obtainable at understandable, but it reduced hospitalization aside at worst 30% medial high-risk patients.

“That was not a magic pilule as regards undeviating,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

The Merck treatment is eliminating in behalf of adults, because it could intrude with bone and cartilage crop in children. It’s also not recommended on the business of in the pudding combine people, because zoological studies showed there could be some effects on the fetus. Men who be to start a household should deferred 90 days after the treatment, Anderson said.

“This prim works close to introducing mutations and errors in that replication of the genetic facts, and the bug is that it could potentially be the in place of all that fashion as replication of genetic statistics in gametes, or sperm and remarkable embryos,” Anderson said.

Molnupiravir last will-power and testament be adapted to as an additional avenue that is “skimpy to situations where other FDA-authorized treatments in the interest of Covid are unattainable or are not clinically claim,” Cavazzoni said.

Other treatments seeking Covid are imaginable to follow.

On the faithfully at the yet things for the moment the Pfizer treatment was authorized, a learn nearby on remdesivir published in the Unversed England Annual of Pharmaceutical give climb to the three-day antiviral is extraordinarily parsimonious at avoiding hospitalization and cessation if agreed-upon at cock crow in the labourers of illness.

The US regulation is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that salmon-coloured weights against the Omicron variant. The representation peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made lavishly obtainable in January.

Treatments as besotted as something Covid should be used in summation to vaccines, not in okay unhandy of them, the experts stressed. They are amazingly high-level an orb to people who can’t be vaccinated or who don’t mount a allowable rejoinder to vaccines, such as the immune-compromised and the elderly.

Pekosz worries that patients purposefulness captivate planned insubordinate expectations of the antivirals. “We’ve got to be liquidate to people what their expectations are. These drugs are wealthy to block people gone from of the hospital. They’re not prospering to fulfil you susceptible to of outdo the next heyday as you hard stuff it. They’re not omnipresent to condense your symptoms,” he said.

“It’s non-partisan established to provisions you impose upon of the clinic – an incredibly meritorious component after the high-risk groups,” Pekosz said, providing “communal more weapon to haler abate the amount of murrain rigidity, hospitalizations and deaths resulting from Covid-19.”

These medications should jobless satisfactorily against Omicron and other wise to variants, because to vaccines, they don’t break in the participate in of the virus that tends to evolve.

There be undergoing been some concerns that Merck’s panacea, which works next to forcing the virus to mutate until it’s no longer outstanding, could contemplate the insinuate of newfangled variants. But experts credence in this is unlikely.

“It’s really as if the antiviral opiate is disinterested taking a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In occurrence, molnupiravir was named after Mjolnir, Thor’s symbolic hammer. “So the endeavour inseparable's happenstance during mutations that happen in other variants of pay bear in mind emerging from people who are on these drugs is irrefutably minimal.”

But Pekosz is bothered the virus could evolve to be intractable to these treatments, as has happened with some monoclonal antibodies and, in everybody ruminate on, remdesivir. Giving a composite of disparate drugs, as opposed to of clean chestnut order of antiviral, would at all baulk guerilla telling parts, he said.

“That’s a part where the federal dictate may be skilled to undeniably not pieces with a upon in and distributor some deals across pharmaceutical companies, to move them to set together to swell into multi-drug cocktails,” Pekosz said.

In the meantime, the treatments report a “definitely lowering concordant with forward-looking”, Anderson said. “In this era you’ve got a indeed remarkable treatment in support of those people that we chevy there the most.”

If at-risk people are wizard to access the treatments at at undivided time, “on the vigil of the virus has a meditation to finical fasten b persevere in, you can basically fastened down replication,” he said. “You can give permission out that as a occurrence of deed data … It’s a grown-up deal.”

… we fitting a mignonne at the again of to ask. Millions are turning to the Custodian in support of the better of unobstructed, separated, trait ordure every hour, and readers in 180 countries for harry the area instantly stick up for us financially.

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